The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we
present DeepLoop, which performs rigorous bias correction followed by deep-learning …

Technological advancements in blood glucose monitoring and therapeutic insulin
administration have improved the quality of life for people with type 1 diabetes. However …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

Findings from the past 10 years have placed the glucagon-secreting pancreatic α-cell centre
stage in the development of diabetes mellitus, a disease affecting almost one in every ten …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …