This Current perspectives article will review and highlight the importance of accurate
diagnosis of patients who have failed to produce specific antibodies to naturally …

Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or
HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that …

Mutations in> 30 genes are known to result in impairment of the adaptive immune system,
causing a group of disorders collectively known as SCID. SCID disorders are split into …

Severe combined immunodeficiency (SCID) comprises a group of disorders that are fatal
owing to genetic defects that abrogate T cell development. Numerous related defects have …

Purpose Primary immunodeficiency (PID) represents disorders with a spectrum of clinical
presentations. The medical community seeks clinical features to prompt evaluation for …

Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a
clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple …

The Primary Immune Deficiency Treatment Consortium (PIDTC) is a collaboration of 41
North American centers studying therapy for rare primary immune deficiency diseases …

This work was partly supported by the National Institute of Allergy and Infectious Diseases,
National Institutes of Health (grant no. 5P01AI076210-04 and grant no. U54AI082973 to …

So far, more than 350 monogenic inborn errors of immunity have been reported, resulting in
a wide range of clinical conditions, including increased susceptibility to severe infections …

Immunoglobulin (IG) replacement therapy has served as lifesaving treatment in primary
immunodeficiency diseases (PID) for more than six decades. Approximately 70% of patients …