Traditionally, opioids exert analgesic effects through actions within the central nervous
system (CNS) exclusively (1). Recently, however, evidence has begun to accumulate that …

measurements of antagonist dissociation constant $, has been substantially supported by
the development of increasingly selective ligands (Table I). The evidence that the receptoors …

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two
endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid …

We have recently developed antisera which recognize epitopes of the cloned delta-opioid
receptor (DOR; Dado et al., 1993). In the present report we have further characterized these …

The release of transmitters at sympathoeffector junctions is not constant, but subject to
modulation by a plethora of different mechanisms. In this respect, presynaptic receptors …

Superfused synaptosomes have been utilized in studies of neurotransmitter release during
25 years. This review summarizes the aspects of neurotransmission that have been and …

Whole-cell patch-clamp recordings were performed together with time-resolved
measurements of membrane capacitance (C m) in nerve terminals acutely dissociated from …

Recent studies suggest that opioids can produce analgesia through peripheral mechanisms
following inflammation of peripheral tissue. This study examined whether opioids …

Abstract Understanding Drugs and Behaviour describes in detail how the main psychoactive
drugs can alter brain chemistry and modify behaviour. Written by experienced lecturers with …

In this article, the effect of nociceptin (orphanin FQ) on transmitter release in the central
nervous system in vitro and in vivo is reviewed. Nociceptin inhibits the electrically or K+ …