Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

The development of chimeric antigen receptor (CAR) T cell therapy has introduced a new
and effective strategy to guide and promote the immune response against tumors in the …

Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

Viruses have been repurposed into tools for gene delivery by transforming them into viral
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

Receptor targeting of vector particles is a key technology to enable cell type–specific in vivo
gene delivery. For example, T cells in humanized mouse models can be modified by …

Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent
years, but improvements are needed. Genetic modification of NK cells with a tumor antigen …

Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …