Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Y Gong, RGJ Klein Wolterink, J Wang, GMJ Bos… - Journal of hematology & …, 2021 - Springer
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …
considered as specialized immune cells that can be genetically modified to obtain capable …
CAR-NK cells: from natural basis to design for kill
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …
recognition domain and numerous intracellular signaling domains that have been …
Engineering NK cells for CAR therapy—recent advances in gene transfer methodology
P Schmidt, MJ Raftery, G Pecher - Frontiers in Immunology, 2021 - frontiersin.org
The development of chimeric antigen receptor (CAR) T cell therapy has introduced a new
and effective strategy to guide and promote the immune response against tumors in the …
and effective strategy to guide and promote the immune response against tumors in the …
Reactivated endogenous retroviruses promote protein aggregate spreading
S Liu, SE Heumüller, A Hossinger, SA Müller… - Nature …, 2023 - nature.com
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …
but the exact mechanisms of intercellular protein aggregate dissemination remain …
Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential
X Wang, X Yang, X Yuan, W Wang, Y Wang - Experimental Hematology & …, 2022 - Springer
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …
Lentiviral vector pseudotypes: precious tools to improve gene modification of hematopoietic cells for research and gene therapy
A Gutierrez-Guerrero, FL Cosset, E Verhoeyen - Viruses, 2020 - mdpi.com
Viruses have been repurposed into tools for gene delivery by transforming them into viral
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …
Materials promoting viral gene delivery
K Kaygisiz, CV Synatschke - Biomaterials Science, 2020 - pubs.rsc.org
Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …
mutations by introducing new genetic information to cells either to correct a faulty gene or to …
Genetic in vivo engineering of human T lymphocytes in mouse models
T Weidner, S Agarwal, S Perian, F Fusil, G Braun… - Nature protocols, 2021 - nature.com
Receptor targeting of vector particles is a key technology to enable cell type–specific in vivo
gene delivery. For example, T cells in humanized mouse models can be modified by …
gene delivery. For example, T cells in humanized mouse models can be modified by …
Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor
Y Gong, RGJK Wolterink, I Janssen, AJ Groot… - … Therapy-Methods & …, 2020 - cell.com
Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent
years, but improvements are needed. Genetic modification of NK cells with a tumor antigen …
years, but improvements are needed. Genetic modification of NK cells with a tumor antigen …
[HTML][HTML] Concise review on optimized methods in production and transduction of lentiviral vectors in order to facilitate immunotherapy and gene therapy
HEG Ghaleh, M Bolandian, R Dorostkar, A Jafari… - Biomedicine & …, 2020 - Elsevier
Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …