Emerging concepts in glaucoma and review of the literature

A Greco, MI Rizzo, A De Virgilio, A Gallo… - The American journal of …, 2016 - Elsevier
Glaucoma is the most commonly acquired optic neuropathy. It represents a public health
challenge because it causes an irreversible blindness. Emerging evidence indicates that the …

Recent developments in ocular drug delivery

H Chen - Journal of drug targeting, 2015 - Taylor & Francis
Ocular drug delivery has many challenges due to the inherent physiology and natural
barriers. Traditionally used eye drops are fairly inefficient with low ocular bioavailability, and …

Discovery of molecular therapeutics for glaucoma: challenges, successes, and promising directions: miniperspective

RK Donegan, RL Lieberman - Journal of medicinal chemistry, 2016 - ACS Publications
Glaucoma, a heterogeneous ocular disorder affecting∼ 60 million people worldwide, is
characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in …

Recent developments in ophthalmic drug delivery systems for therapy of both anterior and posterior segment diseases

H Chen, Y Jin, L Sun, X Li, K Nan, H Liu… - Colloid and interface …, 2018 - Elsevier
Eye is a complex organ with unique anatomy and physiology. The structure of eye can be
divided into two main parts: anterior segment and posterior segment. Due to the special …

Neuroprotection in the treatment of glaucoma–A focus on connexin43 gap junction channel blockers

YS Chen, CR Green, HV Danesh-Meyer… - European Journal of …, 2015 - Elsevier
Glaucoma is a form of optic neuropathy and a common cause of blindness, affecting over 60
million people worldwide with an expected rise to 80 million by 2020. Successful treatment …

Glaucoma: recent advances in the involvement of autoimmunity

MI Rizzo, A Greco, A De Virgilio, A Gallo… - Immunologic …, 2017 - Springer
Glaucomatous optic neuropathy is the most commonly acquired optic neuropathy
encountered in clinical practice. It is the second leading cause of blindness globally, after …

NAD+ and Niacin Supplementation as Possible Treatments for Glaucoma and Age-Related Macular Degeneration: A Narrative Review

MR Gemae, MD Bassi, P Wang, EK Chin, DRP Almeida - Nutrients, 2024 - mdpi.com
Glaucoma and age-related macular degeneration (AMD) are progressive retinal diseases
characterized by increased oxidative stress, inflammation, and mitochondrial dysfunction …

Open-angle glaucoma: drug development pipeline during the last 20 years (1995-2015)

A Vicente, S Prud'homme, J Ferreira… - Ophthalmic …, 2017 - karger.com
Objectives: To analyse drug development for open-angle glaucoma during the last 20 years.
Methods: Research was performed by referring to clinical trials registered at the International …

[HTML][HTML] Promise of latanoprost and timolol loaded combinatorial nanosheet for therapeutic applications in glaucoma

L Wang, YY Jiang, N Lin - Journal of King Saud University-Science, 2020 - Elsevier
To demonstrate a combinatorial drug loaded nanosheet made of alginate and chitosan
which reduces intraocular pressure in a slow and sustained manner depicted by in-vivo …

Translating the low translaminar cribrosa pressure gradient hypothesis into the clinical care of glaucoma

AH Guy, JL Wiggs, A Turalba… - Seminars in …, 2016 - Taylor & Francis
Glaucoma is an optic neuropathy with multiple known risk factors, including age, race, family
history, and intraocular pressure. Unfortunately, the only currently modifiable risk factor in …