It is now possible to grow DC-like cells in culture17-21 and extensive cell membrane
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …

Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …

IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …

The immune status of the tumor microenvironment is a key indicator in determining the
antitumor effectiveness of immunotherapies. Data support the role of activation and …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

Virus-specific CD8+ T cells develop the ability to function in an “innate” capacity by
responding to a remarkable array of cytokines in a TCR-independent manner. Although …

Thymic-dependent differentiation of bone marrow (BM)-derived progenitors and thymic-
independent antigen-driven peripheral expansion of mature T cells represent the 2 primary …

Tumors represent a hostile environment for the effector cells of cancer immunosurveillance.
Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly …

It has been intensively reported that the immunosuppressive tumor microenvironment (TME)
results in tumor resistance to immunotherapy, especially immune checkpoint blockade and …

Discusses the role of cytokines in psoriasis. Features of psoriatic lesions; Behavior of
interleukin (IL)-I-alpha, IL-I beta and tumor necrosis factor-alpha in psoriasis; Role of …