Recent data from several groups demonstrate high levels of IL-7 in the joints of RA patients,
but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of …

IL-7, expressed by stromal cells in primary lymphoid organs, is known for its critical role in
the development and homeostatic expansion of T cells in humans and mice. IL-7 is equally …

Aim Interleukin (IL)‐7 signalling modulates T cell activity and is implicated in numerous
autoimmune diseases. The present study investigated the safety, pharmacokinetics, target …

Interleukin (IL)-7 is a potent immunoregulatory cytokine that is detected in joints of patients
with rheumatoid and juvenile idiopathic arthritis and which correlates with parameters of …

Typically, multiple cytokines act in concert to mediate a desired immunological response,
and thus more effective therapeutics may be achieved by combining several cytokines with …

Leprosy, whose etiologic agent Mycobacterium Ieprae, is an illness of ample clinical and
immunopathological spectrum. Its clinical manifestations are correlated with distinct …

Objective To assess the feasibility, safety, and efficacy of high‐dose chemotherapy and
autologous hematopoietic stem cell transplantation (HSCT) in patients with severe …

OSE-127 is a humanized mAb targeting the IL-7Rα-chain (CD127), under development for
inflammatory and autoimmune disease treatment. It is a strict antagonist of the IL-7R …

Background Diagnostic patch testing in allergic contact dermatitis faces the risk of boosting
existing hypersensitivities or active sensitization. Risk‐free and reliable in vitro assays using …

The role of antigen‐presenting cell (APC)‐derived cytokines in T cell activation is still
controversial. Highly purified CD4 T cell populations of the naive and short‐term Th1 and …