Costimulatory blockade can be used to promote allogeneic marrow engraftment and
tolerance induction, but on its own is not 100% reliable. We sought to determine whether …

Although cytokine support can enhance CAR T-cell function, coadministering cytokines or
engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety …

The role of antigen‐presenting cell (APC)‐derived cytokines in T cell activation is still
controversial. Highly purified CD4 T cell populations of the naive and short‐term Th1 and …

Combination of immunotherapy and chemotherapy has shown promise for cancer.
Interleukin-7 (IL-7) can potentially enhance immune responses against tumor, while …

Abstract The interleukin‐12 receptor (IL‐12R) β1 chain is an essential component of the
functional IL‐12R on both human T and natural killer cells. In this report it is shown that …

Adoptive transfer of antigen-specific cytotoxic T lymphocytes has shown promise for the
therapy of cancer. However, tumor-specific T cells are susceptible to diverse inhibitory …

Dendritic cells can facilitate allograft survival and prevent autoimmunity via direct and
indirect cell-mediated mechanisms. Recent studies demonstrate that immunoregulatory …

Interleukin-7 (IL-7) supports the proliferation of mature T lymphocytes, however, the cellular
source of IL-7 for T lymphocyte activation has not been well established. We therefore …

Interleukin-7 (IL-7) is a growth and anti-apoptotic factor for T-lymphocytes, with potential for
clinical use in the treatment of immunodeficiencies due to loss of T-cells. Lymphopenia …

Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been
extensively studied and is poorly understood. Our work describes a posttranscriptional …