Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

We investigated selection and analysis of tag SNPs for genome-wide association studies by
specifically examining the relationship between investment in genotyping and statistical …

During the last two decades, DNA-based molecular markers have been extensively utilized
for a variety of studies in both plant and animal systems. One of the major uses of these …

Human geneticists working on systems for which it is possible to make a strong case for a
set of candidate genes face the problem of whether it is necessary to consider the variation …

In this review we describe the principles, protocols, and applications of two commercially
available SNP genotyping platforms, the TaqMan® SNP Genotyping Assays and the …

The investigations of patterns of linkage disequilibrium for designing associationmapping
studies are fast becoming a method of interest for complex trait dissection and improvement …

Identifying genes involved in the development of cancer is crucial to fully understanding
cancer biology, for developing novel therapeutics for cancer treatment and for providing …

A major challenge for genomewide disease association studies is the high cost of
genotyping large number of single nucleotide polymorphisms (SNP). The correlations …

Association mapping, also known as linkage disequilibrium mapping, is a relatively new and
promising genetic method for complex trait dissection. Association map ping has the …