[HTML][HTML] The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

RE Vickman, OE Franco, DC Moline… - Asian journal of …, 2020 - Elsevier
Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostate in which
incidence increases linearly with age, beginning at about 50 years old. BPH is a significant …

[HTML][HTML] A cellular anatomy of the normal adult human prostate and prostatic urethra

GH Henry, A Malewska, DB Joseph, VS Malladi, J Lee… - Cell reports, 2018 - cell.com
A comprehensive cellular anatomy of normal human prostate is essential for solving the
cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to …

Prostate luminal progenitor cells: from mouse to human, from health to disease

M Baures, C Dariane, E Tika, E Puig Lombardi… - Nature Reviews …, 2022 - nature.com
Stem and progenitor cells of the adult prostate epithelium have historically been believed to
reside mainly or exclusively within the basal cell compartment and to possess basal-like …

[HTML][HTML] TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease

RE Vickman, LT Aaron-Brooks, R Zhang… - Nature …, 2022 - nature.com
Autoimmune (AI) diseases can affect many organs; however, the prostate has not been
considered to be a primary target of these systemic inflammatory processes. Here, we utilize …

5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia

DB Joseph, GH Henry, A Malewska… - The Journal of …, 2022 - Wiley Online Library
Benign prostatic hyperplasia (BPH) is a progressive expansion of peri‐urethral prostate
tissue common in aging men. Patients with enlarged prostates are treated with 5‐alpha …

Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate

DB Joseph, GH Henry, A Malewska, NS Iqbal… - The …, 2020 - Wiley Online Library
Background Castration‐insensitive epithelial progenitors capable of regenerating the
prostate have been proposed to be concentrated in the proximal region based on facultative …

[HTML][HTML] Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes

D Liu, JE Shoag, D Poliak, RS Goueli… - Nature …, 2020 - nature.com
Benign prostatic hyperplasia (BPH), a nonmalignant enlargement of the prostate, is among
the most common diseases affecting aging men, but the underlying molecular features …

[HTML][HTML] Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic …

X Fei, J Liu, J Xu, H Jing, Z Cai, J Yan, Z Wu… - Journal of Translational …, 2024 - Springer
Objective Proliferative nodular formation represents a characteristic pathological feature of
benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume …

[HTML][HTML] Functional heterogeneity of mouse prostate stromal cells revealed by single-cell RNA-seq

OJ Kwon, Y Zhang, Y Li, X Wei, L Zhang, R Chen… - IScience, 2019 - cell.com
We perform a single-cell RNA sequencing analysis to investigate the phenotypic and
functional heterogeneity of the adult mouse prostate stromal cells. Our analysis identifies …

[HTML][HTML] Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing …

M Zhang, C Luo, K Cui, T Xiong, Z Chen - World journal of urology, 2020 - Springer
Objective Inflammation plays an important role in the development of benign prostatic
hyperplasia (BPH). The aim of the present study was to reference the study of the …