[HTML][HTML] SARS-CoV-2 and the spike protein in endotheliopathy
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …
compartment in the upper and lower airways. There is evidence that the microvasculature in …
[HTML][HTML] Coagulation and complement: Key innate defense participants in a seamless web
ELG Pryzdial, A Leatherdale, EM Conway - Frontiers in Immunology, 2022 - frontiersin.org
In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …
activated and complement is regulated, wrote,“In the study of biological processes, the …
[HTML][HTML] Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …
activation are hallmarks of neurological diseases and emerging therapeutic targets …
Cell-specific mechanisms in the heart of COVID-19 patients
From the onset of the pandemic, evidence of cardiac involvement in acute COVID-19
abounded. Cardiac presentations ranged from arrhythmias to ischemia, myopericarditis …
abounded. Cardiac presentations ranged from arrhythmias to ischemia, myopericarditis …
Renin-angiotensin system and sex differences in COVID-19: a critical assessment
MC Chappell - Circulation Research, 2023 - Am Heart Assoc
The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …
health burden that became the third leading cause of death and potentially contributed to a …
[HTML][HTML] ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
[HTML][HTML] SERPING1 Variants and C1-INH Biological Function: A Close Relationship With C1-INH-HAE
Hereditary angioedema with C1 Inhibitor deficiency (C1-INH-HAE) is caused by a
constellation of variants of the SERPING1 gene (n= 809; 1,494 pedigrees), accounting for …
constellation of variants of the SERPING1 gene (n= 809; 1,494 pedigrees), accounting for …
[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know
WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …
[HTML][HTML] Biochemical aspects of the inflammatory process: A narrative review
CLR Soares, P Wilairatana, LR Silva… - Biomedicine & …, 2023 - Elsevier
Inflammation is a protective response of the body potentially caused by microbial, viral, or
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …
Complement in human disease: approved and up-and-coming therapeutics
EE West, T Woodruff, V Fremeaux-Bacchi, C Kemper - The Lancet, 2023 - thelancet.com
The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …
controller of immune system and tissue homoeostasis. However, dysregulated complement …