Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …

The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …

A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …

CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …

The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a
member of the importin β superfamily of nuclear transport receptors, recognizing proteins …

Transcriptional control mechanisms chart the course of the inflammatory response by
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …

Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …

High tumor recurrence is frequently observed in patients with urinary bladder cancers
(UBCs), with the need for biomarkers of prognosis and drug response. Chemoresistance …

Long noncoding RNAs (lncRNAs) play an important role in the development and
progression of cancers. However, the clinical significances of lncRNAs and their functions …