Enhancing sepsis biomarker development: key considerations from public and private perspectives

JF Llitjos, ED Carrol, MF Osuchowski, M Bonneville… - Critical Care, 2024 - Springer
Implementation of biomarkers in sepsis and septic shock in emergency situations, remains
highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to …

Septic shock in the immunocompromised cancer patient: a narrative review

JL Nates, F Pène, M Darmon, D Mokart, P Castro… - Critical Care, 2024 - Springer
Immunosuppressed patients, particularly those with cancer, represent a momentous and
increasing portion of the population, especially as cancer incidence rises with population …

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

R Silva-Gomes, I Caldeira, R Fernandes… - Journal of Leukocyte …, 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …

The clinical application of metagenomic next-generation sequencing in immunocompromised patients with severe respiratory infections in the ICU

J Zhao, Y Sun, J Tang, K Guo, K Wang, J Zhuge… - Respiratory …, 2024 - Springer
Background Early targeted antibiotic therapy is crucial for improving the prognosis of
immunocompromised patients with severe respiratory infections (SRIs) in the intensive care …

Rapid multiplex PCR panels for the management of ventilator-associated pneumonia: pondering strengths and weaknesses

M Tomasello, D Mangioni, M Panigada… - Intensive Care …, 2024 - Springer
We read with interest the review by Kreitmann et al. on intensive care unit (ICU)-acquired
infections in immunocompromised patients [1]. The authors nicely discussed conditions …

Advancements in nanosensors for detecting pathogens in healthcare environments

A Bruno, F Tripodi, A Armanni, L Barbieri… - Environmental …, 2024 - pubs.rsc.org
Hospitals serve as critical environments for the management of diverse medical conditions,
ranging from routine illnesses to life-threatening emergencies. However, alongside …

[HTML][HTML] Monitoring Immune Dysfunction in Critically Ill Patients with Carbapenem-Resistant Acinetobacter baumannii Sepsis Treated with Regimens Including …

A Frattari, E Polilli, L Timelli, F Spagnuolo, P Fazii… - Antibiotics, 2024 - mdpi.com
Background: Multidrug-resistant Acinetobacter baumannii (CRAB) infections are a serious
problem in critical care. This study aims to develop an early prognostic score for immune …

Practical Lessons on Antimicrobial Therapy for Critically Ill Patients

R Cusack, E Little, I Martin-Loeches - Antibiotics, 2024 - mdpi.com
Sepsis stands as a formidable global health challenge, with persistently elevated mortality
rates in recent decades. Each year, sepsis not only contributes to heightened morbidity but …

Invasive fungal infections in non-neutropenic patients

L Kreitmann, S Blot, S Nseir - Intensive Care Medicine, 2024 - Springer
Invasive candidiasis (IC) refers to systemic infections by yeasts belonging to the genus
Candida. C. albicans remains the dominant strain, but the epidemiology of IC is changing …

Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study

G Zebian, L Kreitmann, M Houard, A Piantoni… - Annals of Intensive …, 2024 - Springer
Background Immunosuppression at intensive care unit (ICU) admission has been
associated with a higher incidence of ICU-acquired infections, some of them related to …