Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Background Patients with depression who are treated in primary care practices may receive
antidepressants for prolonged periods. Data are limited on the effects of maintaining or …

Background Exercise may be a promising target for depression interventions. However,
evidence for a beneficial effect of exercise interventions on the prevention of depression …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults …

Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …

Major depression is often a relapsing disorder. It is therefore important to start its treatment
with therapies that maximize the chance of not only getting the patients well but also keeping …

Major depression is one of the leading causes of disability, morbidity, and mortality
worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the …