Simple Summary Individual patients with liver cancer have a highly variable clinical course.
Hence, there is an urgent need to identify new prognostic markers to determine prognosis …

Cellular metabolism is not only essential for tumor cells to sustain their rapid growth and
proliferation, but also crucial to maintain T cell fitness and robust immunity. Dysregulated …

Advanced and aggressive prostate cancer (PCa) depends on glutamine for survival and
proliferation. We have previously shown that inhibition of glutaminase 1, which catalyzes the …

Dihydroorotase (DHOase) is the third enzyme in the de novo biosynthesis pathway for
pyrimidine nucleotides, and an attractive target for potential anticancer chemotherapy. By …

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated
metabolism in GBM offers an opportunity to deploy metabolic interventions as precise …

Metabolic reprogramming is a hallmark of cancer progression. Metabolic activity supports
tumorigenesis and tumor progression, allowing cells to uptake essential nutrients from the …

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells,
and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment …

Simple Summary Metabolic reprogramming in glioblastoma is a hallmark of malignancy.
Metabolic enzymes and metabolites participate in energetic metabolism and function as …

Metabolic reprogramming is an integral part of the growth-promoting program driven by the
MYC family of oncogenes. However, this reprogramming also imposes metabolic …

Chemotherapy resistance is considered one of the main causes of tumor relapse, still
challenging researchers for the identification of the molecular mechanisms sustaining its …