Increasing adipose tissue mass in obesity directly correlates with elevated circulating leptin
levels. Leptin is an adipokine known to play a role in numerous biological processes …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

Rationale: NT-proBNP (N-terminal pro–brain natriuretic peptide), a biomarker of cardiac
origin, is used to risk stratify patients with pulmonary arterial hypertension (PAH). Its …

OBJECTIVE Preclinical studies have suggested that thrombospondin-2 (TSP2) is implicated
in liver fibrosis. However, the clinical relevance of TSP2 in nonalcoholic fatty liver disease …

Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

Glucose variability (GV) has been recognized recently as a promoter of complications and
therapeutic targets in diabetes. The aim of this study was to reconstruct and analyze gene …

Pulmonary artery hypertension (PAH) pathology involves extracellular matrix (ECM)
remodeling in cardiac tissues, thus promoting cardiac fibrosis progression. miR-29a-3p …

Breast cancer (bc) is the second most common type of human malignancies with highest
morbidity and mortality in the female population. Therefore, it is essential to develop novel …

Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The
underlying pathology is mainly driven by the abnormal immune responses including …

EVs are membranous subcellular structures originating from various cells, including
platelets which consist of biomolecules that can modify the target cell's pathophysiological …