The human body is a highly aerobic organism, which needs large amount of oxygen,
especially in tissues characterized by high metabolic demand, such as the heart. Inadequate …

Increased ventilation relative to metabolic demands, indicating alveolar hyperventilation
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …

Background: Progressive exercise intolerance is a hallmark of pulmonary hypertension (pH),
severely impacting patients' independence and quality of life (QoL). Accumulating evidence …

BACKGROUND: This study aims to assess the impact of sotatercept on exercise tolerance,
exercise capacity, and right ventricular function in pulmonary arterial hypertension …

Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that
is in urgent need of improved therapies that treat it. One of the remaining therapeutic …

Introduction: The right ventricle (RV) mechanical property is an important determinant of its
function. However, compared to its elasticity, RV viscoelasticity is much less studied, and it …

Extract Impairment of exercise capacity, predominantly limited symptomatically by dyspnoea
[1], affects most patients with pulmonary arterial hypertension (PAH) despite current …

Background The symptom for identification of pulmonary arterial hypertension (PAH) is
dyspnea on exertion, with a concomitant decrease in exercise capacity. Even patients with …

Background The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through
metabolic acidosis mediated by renal bicarbonate excretion. In animal models …

Background Skeletal muscle deficits are associated with worse exercise performance in
adults with pulmonary hypertension (PH) but the impact is poorly understood in pediatric PH …