[HTML][HTML] New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from …
M Oknińska, U Mackiewicz, K Zajda, C Kieda… - Biomedicine & …, 2022 - Elsevier
The human body is a highly aerobic organism, which needs large amount of oxygen,
especially in tissues characterized by high metabolic demand, such as the heart. Inadequate …
especially in tissues characterized by high metabolic demand, such as the heart. Inadequate …
Excess ventilation and exertional dyspnoea in heart failure and pulmonary hypertension
Increased ventilation relative to metabolic demands, indicating alveolar hyperventilation
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …
Respiratory, cardiovascular and musculoskeletal mechanisms involved in the pathophysiology of pulmonary hypertension: An updated systematic review of preclinical …
TC Freire, MS Ferreira, K De Angelis, M Paula-Ribeiro - Heart & Lung, 2024 - Elsevier
Background: Progressive exercise intolerance is a hallmark of pulmonary hypertension (pH),
severely impacting patients' independence and quality of life (QoL). Accumulating evidence …
severely impacting patients' independence and quality of life (QoL). Accumulating evidence …
SPECTRA phase 2b study: impact of sotatercept on exercise tolerance and right ventricular function in pulmonary arterial hypertension
AB Waxman, DM Systrom, S Manimaran… - Circulation: Heart …, 2024 - Am Heart Assoc
BACKGROUND: This study aims to assess the impact of sotatercept on exercise tolerance,
exercise capacity, and right ventricular function in pulmonary arterial hypertension …
exercise capacity, and right ventricular function in pulmonary arterial hypertension …
Skeletal muscle dysfunction in experimental pulmonary hypertension
K Kosmas, Z Michael, AE Papathanasiou… - International journal of …, 2022 - mdpi.com
Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that
is in urgent need of improved therapies that treat it. One of the remaining therapeutic …
is in urgent need of improved therapies that treat it. One of the remaining therapeutic …
Alterations of biaxial viscoelastic properties of the right ventricle in pulmonary hypertension development in rest and acute stress conditions
Introduction: The right ventricle (RV) mechanical property is an important determinant of its
function. However, compared to its elasticity, RV viscoelasticity is much less studied, and it …
function. However, compared to its elasticity, RV viscoelasticity is much less studied, and it …
The skeletal muscle metaboreflex: a novel driver of ventilation, dyspnoea and pulmonary haemodynamics during exercise in pulmonary arterial hypertension
MJ Plunkett, ALC Sayegh… - European …, 2024 - Eur Respiratory Soc
Extract Impairment of exercise capacity, predominantly limited symptomatically by dyspnoea
[1], affects most patients with pulmonary arterial hypertension (PAH) despite current …
[1], affects most patients with pulmonary arterial hypertension (PAH) despite current …
Exercise capacity and ventilatory efficiency in patients with pulmonary arterial hypertension
K Tobita, A Goda, K Teruya, Y Nishida… - Journal of the …, 2023 - Am Heart Assoc
Background The symptom for identification of pulmonary arterial hypertension (PAH) is
dyspnea on exertion, with a concomitant decrease in exercise capacity. Even patients with …
dyspnea on exertion, with a concomitant decrease in exercise capacity. Even patients with …
[HTML][HTML] Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: a randomized, double-blind, cross-over trial
M Lichtblau, S Saxer, J Müller, P Appenzeller, C Berlier… - Pulmonology, 2024 - Elsevier
Background The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through
metabolic acidosis mediated by renal bicarbonate excretion. In animal models …
metabolic acidosis mediated by renal bicarbonate excretion. In animal models …
Skeletal muscle deficits are associated with worse exercise performance in pediatric pulmonary hypertension
CM Avitabile, MG McBride, MA Harris… - Frontiers in …, 2022 - frontiersin.org
Background Skeletal muscle deficits are associated with worse exercise performance in
adults with pulmonary hypertension (PH) but the impact is poorly understood in pediatric PH …
adults with pulmonary hypertension (PH) but the impact is poorly understood in pediatric PH …