[HTML][HTML] Antibiotics in the clinical pipeline as of December 2022
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …
resistant bacterial infections has clearly attracted global attention, with a range of existing …
Small-molecule antibiotic drug development: need and challenges
M Bergkessel, B Forte, IH Gilbert - ACS Infectious Diseases, 2023 - ACS Publications
The need for new antibiotics is urgent. Antimicrobial resistance is rising, although currently,
many more people die from drug-sensitive bacterial infections. The continued evolution of …
many more people die from drug-sensitive bacterial infections. The continued evolution of …
Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges
H Liu, Y Yu, A Dong, M Elsabahy, YW Yang… - Exploration, 2024 - Wiley Online Library
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …
Glycoconjugate vaccines against antimicrobial resistant pathogens
C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics
The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …
Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance
The increasing number of bacterial infections globally that do not respond to any available
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …
Empowering low-and middle-income countries to combat AMR by minimal use of antibiotics: A way forward
M Kanan, M Ramadan, H Haif, B Abdullah, J Mubarak… - Antibiotics, 2023 - mdpi.com
Antibiotic overuse poses a critical global health concern, especially in low-and middle-
income countries (LMICs) where access to quality healthcare and effective regulatory …
income countries (LMICs) where access to quality healthcare and effective regulatory …
Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions
Antimicrobial resistance (AMR) is a global health challenge that threatens humans, animals
and the environment. Evidence is emerging for a role of healthcare infrastructure …
and the environment. Evidence is emerging for a role of healthcare infrastructure …
The overlooked bacterial pandemic
The COVID-19 pandemic had a significant economic and health impact worldwide. It also
reinforced the misperception that only viruses can pose a threat to human existence …
reinforced the misperception that only viruses can pose a threat to human existence …
Vaccine development for bacterial pathogens: Advances, challenges and prospects
IE Mba, HC Sharndama… - Tropical Medicine & …, 2023 - Wiley Online Library
The advent and use of antimicrobials have played a key role in treating potentially life‐
threatening infectious diseases, improving health, and saving the lives of millions of people …
threatening infectious diseases, improving health, and saving the lives of millions of people …