Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …

Autophagy, a vital catabolic process that degrades cytoplasmic components within the
lysosome, is an essential cytoprotective response to pathologic stresses that occur during …

Autophagy is a conserved cellular process for bulk degradation of intracellular protein and
organelles in lysosomes. In contrast to elegant studies of beclin1 using mouse models and …

Autophagy is a catabolic process that turns over long-lived proteins and organelles and
contributes to cell and organism survival in times of stress. Current cancer therapies …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Vitamin D is involved in mineral and bone homeostasis, immune responses, anti-
inflammation, anti-infection, and cancer prevention. Vitamin D receptor (VDR) is a nuclear …

Abstract Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by
multiple enzymes that are differentially expressed in the peripheral tissues and central …

Significance: Lysosomes are acidic organelles containing more than fifty hydrolases that
provide for the degradation of intracellular and endocytosed materials by autophagy and …