Residents of distressed urban areas suffer early aging-related disease and excess mortality.
Using a community-based participatory research approach in a collaboration between social …

Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Epigenetics is a burgeoning area of biomedical research into the mechanisms by which
genes are regulated—how the activity of producing proteins is controlled. Although …

The discovery of steroid hormone receptors in brain regions that mediate every aspect of
brain function has broadened the definition of 'neuroendocrinology'to include the reciprocal …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

DNA methylation patterns are important for establishing cell, tissue, and organism
phenotypes, but little is known about their contribution to natural human variation. To …

Abnormalities of enamel and dentine are caused by a variety of interacting factors ranging
from genetic defects to environmental insults. The genetic changes associated with some …

Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …

Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …