Desorption electrospray ionization and matrix-assisted laser desorption/ionization as imaging approaches for biological samples analysis
The imaging of biological tissues can offer valuable information about the sample
composition, which improves the understanding of analyte distribution in such complex …
composition, which improves the understanding of analyte distribution in such complex …
Advances in tissue section preparation for MALDI imaging MS
A Thomas, P Chaurand - Bioanalysis, 2014 - Taylor & Francis
Enriched by a decade of remarkable developments, matrix-assisted laser desorption
ionization imaging mass spectrometry (MALDI IMS) has witnessed a phenomenal …
ionization imaging mass spectrometry (MALDI IMS) has witnessed a phenomenal …
Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization
Glucuronidation is a common phase II metabolic process for drugs and xenobiotics which
increases their solubility for excretion. Acyl glucuronides (glucuronides of carboxylic acids) …
increases their solubility for excretion. Acyl glucuronides (glucuronides of carboxylic acids) …
Sample preparation for mass spectrometry imaging of leaf tissues: a case study on analyte delocalization
Appropriate sample preparation is pivotally important to obtain high-quality mass
spectrometry imaging (MSI) data. Unlike mammalian tissues, preparation of cryosections …
spectrometry imaging (MSI) data. Unlike mammalian tissues, preparation of cryosections …
In situ hydrogel conditioning of tissue samples to enhance the drug's sensitivity in ambient mass spectrometry imaging
X Song, Z Luo, X Li, T Li, Z Wang, C Sun… - Analytical …, 2017 - ACS Publications
Ion suppression from the tissue matrix has a severe effect on the mass spectrometry imaging
(MSI) of drugs. This problem hinders further applications of MSI in preclinical drug research …
(MSI) of drugs. This problem hinders further applications of MSI in preclinical drug research …
Correlated imaging–a grand challenge in chemical analysis
Correlated chemical imaging is an emerging strategy for acquisition of images by combining
information from multiplexed measurement platforms to track, visualize, and interpret in situ …
information from multiplexed measurement platforms to track, visualize, and interpret in situ …
Development of an integrated tissue pretreatment protocol for enhanced MALDI MS imaging of drug distribution in the brain
The matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI)
technique has attracted intense interest in the visualization of drug distribution in tissues. Its …
technique has attracted intense interest in the visualization of drug distribution in tissues. Its …
[HTML][HTML] Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer
Accurate localization of central nervous system (CNS) drug distribution in the brain is quite
challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry …
challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry …
Challenges and recent advances in mass spectrometric imaging of neurotransmitters
Mass spectrometric imaging (MSI) is a powerful tool that grants the ability to investigate a
broad mass range of molecules, from small molecules to large proteins, by creating detailed …
broad mass range of molecules, from small molecules to large proteins, by creating detailed …
Preparation of frozen sections of multicellular tumor spheroids coated with ice for mass spectrometry imaging
P Xie, C Zhao, X Liang, W Huang, Y Chen… - Analytical …, 2020 - ACS Publications
Increasing studies have utilized mass spectrometry imaging (MSI) that is a label-free tool to
investigate drug penetration and drug biotransformation in multicellular tumor spheroids …
investigate drug penetration and drug biotransformation in multicellular tumor spheroids …