Among the most typical posttranslational modifications is glycosylation, which often involves
the covalent binding of an oligosaccharide (glycan) to either an asparagine (N-linked) or a …

A vital process in drug discovery and development is to assess the absorption, distribution,
metabolism, excretion and toxicology of potentially therapeutic compounds in the body. The …

MS imaging has rapidly evolved over the last decade, finding roles in all aspects of
pharmaceutical research and development. This article discusses possible methodological …

The complex neoplastic tissue and its microenvironment often posit intratumor
heterogeneity, affecting drug molecule distribution in the tumor. A deep understanding of the …

摘要质谱成像是一种在组织, 细胞或亚细胞水平研究分子或离子种类及分布的新型分析技术,
无需复杂前处理即可实现样本表面多种物质的原位定性, 定量分析, 绘制出它们的空间分布图 …

Mass spectrometry imaging (MSI) has become a significant technique of mass spectrometry
(MS) to visualize the spatial distribution of molecules such as drugs, metabolites, lipids, and …

Mass spectrometry imaging (MSI) and mass spectrometry (MS) profiling are two especially
suitable methods for recording and visualizing microscopic molecular details. Mass …

Neuropeptides, including peptide hormones, are key modulators in the brain that represent
the largest class of chemical messengers for cell-to-cell communication. 1–5 Due to the …

This translational project is focused on the effects of oxidative stress on the diagnosis and
stratification of diabetic nephropathy (DN). In Chapter 1, the production of AGEs and post …