Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer

LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

Technologies enabling single-molecule super-resolution imaging of mRNA

M Tingey, SJ Schnell, W Yu, J Saredy, S Junod, D Patel… - Cells, 2022 - mdpi.com
The transient nature of RNA has rendered it one of the more difficult biological targets for
imaging. This difficulty stems both from the physical properties of RNA as well as the …

YTHDF3 facilitates eIF2AK2 and eIF3A recruitment on mRNAs to regulate translational processes in oxaliplatin-resistant colorectal cancer

Y Zhao, H Zhao, D Zhang, Q Quan, Y Ge… - ACS Chemical …, 2022 - ACS Publications
Oxaliplatin, as a first-line drug, frequently causes chemo-resistance in colorectal cancer
(CRC). The role of N6-methyladenosine (m6A) modification in multiple biological functions …

ELAVL1 promotes prostate cancer progression by interacting with other m6A regulators

Z Cai, H Xu, G Bai, H Hu, D Wang, H Li… - Frontiers in oncology, 2022 - frontiersin.org
N6-Methyladenosine (m6A) imbalance is an important factor in the occurrence and
development of prostate cancer (PCa). Many m6A regulators have been found to be …

Epigenetic modifications in prostate cancer metastasis and microenvironment

S Zhang, T Shen, Y Zeng - Cancers, 2023 - mdpi.com
Simple Summary Epigenetics, which leads to specific differentiation events and determines
gene expression states, has been recognized as a developmental landscape. Epigenetic …

RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68

Q Nie, X Wu, Y Huang, T Guo, J Kuang… - European Journal of …, 2023 - Springer
Purpose There is no report about the direct relationship between m6A modification and
androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the …

scTIGER: A Deep-Learning Method for Inferring Gene Regulatory Networks from Case versus Control scRNA-seq Datasets

M Dautle, S Zhang, Y Chen - International Journal of Molecular Sciences, 2023 - mdpi.com
Inferring gene regulatory networks (GRNs) from single-cell RNA-seq (scRNA-seq) data is an
important computational question to find regulatory mechanisms involved in fundamental …

Stress granules: stress-induced cytoplasmic mRNPs compartments linked to mRNA translational regulatory pathways

P Adjibade, R Mazroui - Frontiers in RNA Research, 2023 - frontiersin.org
Stress granules (SG) are macro-complexes that assemble as phase-separated and dynamic
RNA biocondensates in the cytoplasm of the eukaryotic cell when the initiation step of the …

Melatonin alleviates heat stress-induced testicular damage in dairy goats by inhibiting the PI3K/AKT signaling pathway

Y Liu, H Cai, X Guo, A Aierken, J Hua, B Ma, S Peng - Stress Biology, 2022 - Springer
Current measures mainly focus on how melatonin reduces physiological heat stress in
animals, but its effects on reproductive damage to male dairy goats have been neglected …

Recent advances in the interplay between stress granules and m6A RNA modification

L Sun, Z Zuo, X Qiu, G Wang, Q Li, J Qiu… - Current Opinion in Solid …, 2023 - Elsevier
Stress granules (SGs) are non-membranous organelles driven by the liquid–liquid phase
separation (LLPS) of RNA and RNA-binding proteins under various stress conditions. LLPS …