Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …

Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people
worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to …

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases
including osteoarthritis (OA), in part via expression of a senescence-associated secretory …

Background Guselkumab, an anti‐interleukin‐23 monoclonal antibody, has demonstrated
significant efficacy in phase III psoriasis trials. Objectives To evaluate the efficacy and safety …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

In this study we examined the metabolic requirements of human T helper cells and the effect
of manipulating metabolic pathways in Th17 and Treg cells. The Th17: Treg cell axis is …

Objective To compare the efficacy and safety of brodalumab, an interleukin-17 receptor
subunit A inhibitor, with placebo, in patients with psoriatic arthritis (PsA). Methods Adult …

abstract Discoveries from basic science research in the last decade have brought significant
progress in knowledge of pathophysiologic processes of allergic diseases, with a …

Generalized pustular psoriasis (GPP) is a severe inflammatory skin disease characterized
by the presence of sterile pustules covering almost the entire body and systemic symptoms …

The discovery of the biological functions of the interleukin-23/-17 axis led to the identification
of IL-23 and IL-17 as important participants in the pathogenesis of several immune-mediated …