IgA nephropathy (IgAN) is the most common glomerulonephritis. It is characterized by the
deposition of immune complexes containing immunoglobulin A (IgA) in the kidney's …

Background MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–
25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated …

The International IgA Nephropathy (IgAN) Prediction Tool is the preferred method in the
2021 KDIGO guidelines to predict, at the time of kidney biopsy, the risk of a 50% drop in …

Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of
harmful substances, in order to maintain cellular integrity. The content of extracellular …

Renal interstitial fibrosis (RIF) is a common pathological feature contributing to chronic injury
and maladaptive repair following acute kidney injury. Currently, there is no effective therapy …

Mesangial cell (MC) proliferation and matrix expansion are basic pathological
characteristics of IgA nephropathy (IgAN). However, the stepwise mechanism of MC …

Hypoxia is the key pathobiological trigger of tubular oxidative stress and cell death that
drives the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). The …

Background IgA nephropathy (IgAN) is the most common primary GN worldwide. Circulating
immune complexes form that are prone to deposition in the mesangium, where they trigger …

IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an
estimated annual incidence of 25 per million adults. Despite optimized supportive care …

Abstract Background IgA nephropathy (IgAN) is the most common form of primary
glomerulonephritis worldwide, and its diagnosis depends mainly on renal biopsy. However …