The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …

The transient receptor potential (TRP) superfamily of ion channels in humans comprises
voltage-gated, non-selective cation channels expressed both in excitable as well as non …

Paclitaxel (PTX) is an anti-microtubule agent, used for the treatment of various types of
cancers; however, it produces painful neuropathy which limits its use. Many neuroprotective …

To discover mode-selective TRPV1 antagonists as thermoneutral drug candidates, the
previous potent antagonist benzopyridone 2 was optimized based on the pharmacophore A …

Pain-relief is a long-term research hotspot with huge demand in clinical treatment. The
analgesics currently used have several side effects, such as being addictive and causing …

Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that
causes neuropathic pain and negatively affects the quality of life. The management of PDN …

The TRPV1 receptor has been recognized to play a role in cancer development, being
overexpressed in prostate, breast, lung, and colon cancers. Since TRPV1 activation …

Abstract A series of 1, 4-benzoxazin-3-one analogs were investigated to discover mode-
selective TRPV1 antagonists, since such antagonists are predicted to minimize target-based …

Chemoselective O‐alkylation of 1‐aryl‐3‐polyfluoroalkylpyrazol‐5‐oles under basic
conditions resulted in a series of 5‐alkoxypyrazoles (26 derivatives). They showed an …

Neuropathy is a terrible disorder that has a wide range of etiologies. Drug-induced
neuropathy, which happens whenever a chemical agent damages the peripheral nerve …