Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …
and pathological situations. Accordingly, alterations in autophagy have been linked to …
Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke
B Han, Y Zhang, Y Zhang, Y Bai, X Chen, R Huang… - Autophagy, 2018 - Taylor & Francis
Circular RNAs (circRNAs) are highly expressed in the central nervous system and are
involved in the regulation of physiological and pathophysiological processes. However, the …
involved in the regulation of physiological and pathophysiological processes. However, the …
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction
QI He, Z Li, Y Wang, Y Hou, L Li, J Zhao - International …, 2017 - Elsevier
Resveratrol has been reported to protect against cerebral ischemia/reperfusion (I/R) injury in
rats, but the underlying mechanism is unclear. In the current study, we examined whether …
rats, but the underlying mechanism is unclear. In the current study, we examined whether …
Autophagy in acute brain injury
Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated …
Background Our previous studies demonstrated that autophagy alleviates cerebral I/R injury
by inhibiting NLRP3 inflammasome-mediated inflammation. 6-Gingerol, a phenolic …
by inhibiting NLRP3 inflammasome-mediated inflammation. 6-Gingerol, a phenolic …
Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's …
M Huang, X Jiang, Y Liang, Q Liu, S Chen… - Experimental gerontology, 2017 - Elsevier
This study investigates the neuroprotective properties of berberine (a natural isoquinoline
alkaloid isolated from the Rhizoma coptidis) and finds that berberine could promote β …
alkaloid isolated from the Rhizoma coptidis) and finds that berberine could promote β …
Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury
B Sun, H Ou, F Ren, Y Huan, T Zhong, M Gao, H Cai - Molecular Medicine, 2018 - Springer
Background The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion
(I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective …
(I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective …
Selenomethionine mitigates cognitive decline by targeting both tau hyperphosphorylation and autophagic clearance in an Alzheimer's disease mouse model
ZH Zhang, QY Wu, R Zheng, C Chen… - Journal of …, 2017 - Soc Neuroscience
Tau pathology was recently identified as a key driver of disease progression and an
attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a …
attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a …
PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window
Z Shen, Y Zheng, J Wu, Y Chen, X Wu, Y Zhou… - Autophagy, 2017 - Taylor & Francis
Prompt reperfusion after cerebral ischemia is critical for neuronal survival. Any strategies
that extend the limited reperfusion window will be of great importance. Acidic …
that extend the limited reperfusion window will be of great importance. Acidic …