Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
M Ajami, H Pazoki-Toroudi, H Amani, SF Nabavi… - Neuroscience & …, 2017 - Elsevier
Searching for effective therapeutic agents to prevent neurodegeneration is a challenging
task due to the growing list of neurodegenerative disorders associated with a multitude of …
task due to the growing list of neurodegenerative disorders associated with a multitude of …
[HTML][HTML] Exercise and neuroinflammation in health and disease
DY Seo, JW Heo, JR Ko, HB Kwak - International neurourology …, 2019 - ncbi.nlm.nih.gov
Neuroinflammation is a central pathological feature of several acute and chronic brain
diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral …
diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral …
Regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia
S Madireddy, S Madireddy - Brain Sciences, 2020 - mdpi.com
The biochemical integrity of the brain is paramount to the function of the central nervous
system, and oxidative stress is a key contributor to cerebral biochemical impairment …
system, and oxidative stress is a key contributor to cerebral biochemical impairment …
Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress
The effects of high (H)-fructose (FR) diet (D)(HFRD) on hepatic lipid homeostasis, oxidative
stress, inflammation and hepatocyte apoptosis were investigated in 6-week old female …
stress, inflammation and hepatocyte apoptosis were investigated in 6-week old female …
[PDF][PDF] Regulation of mitochondrial gene expression, the epigenetic enigma
A Mposhi, MG Van der Wijst, KN Faber… - Front Biosci (Landmark …, 2017 - core.ac.uk
Epigenetics provides an important layer of information on top of the DNA sequence and is
essential for establishing gene expression profiles. Extensive studies have shown that …
essential for establishing gene expression profiles. Extensive studies have shown that …
Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease
SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and
motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes …
motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes …
Thermos-responsive hydrogel system encapsulated engineered exosomes attenuate inflammation and oxidative damage in acute spinal cord injury
Y Xiao, X Hu, P Jiang, Z Qi - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Introduction: Spinal cord injury (SCI) is a serious and disabling condition, and the
effectiveness of conventional treatment is limited, such as supportive treatment and …
effectiveness of conventional treatment is limited, such as supportive treatment and …
Mitochondrial bioenergy in neurodegenerative disease: Huntington and Parkinson
Strong evidence suggests a correlation between degeneration and mitochondrial deficiency.
Typical cases of degeneration can be observed in physiological phenomena (ie, ageing) as …
Typical cases of degeneration can be observed in physiological phenomena (ie, ageing) as …
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy
B Xu, Z Zhou, J Fang, J Wang, K Tao, J Liu… - Free Radical Biology and …, 2023 - Elsevier
Although spinal cord injury (SCI) represents a primary etiology of disability, currently, there
are exist limited viable therapies modalities. Acquiring comprehension of the diverse …
are exist limited viable therapies modalities. Acquiring comprehension of the diverse …
Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …