Background Microglia, the mononuclear immune cells of the central nervous system (CNS),
are essential for the maintenance of CNS homeostasis. BAP31, a resident and ubiquitously …

Human caseinolytic protease P (Hs ClpP), an ATP-dependent unfolding peptidase protein in
the mitochondrial matrix, controls protein quality, regulates mitochondrial metabolism, and …

Background Aging is an inevitable physiological process, associated with a decline in
cognitive function. Recently, metformin, as the first-line treatment for type II diabetes, has …

Alzheimer's disease (AD) is a neurodegenerative disease with an increasing morbidity,
mortality, and economic cost. Plaques formed by amyloid beta peptide (Aβ) and …

The underlying mechanisms for increased neurodegeneration and neurocognitive deficits in
HIV-infected people are unclear. Therefore, this study was aimed to investigate the …

Aims: Traumatic brain injury (TBI) is a major cause of disability and death, and a better
understanding of the underlying mechanisms of mitochondrial dysfunction will provide …

Bifenthrin is one of the widely used synthetic pyrethroid insecticides, employed for various
purposes worldwide. As lipophilic pyrethroids can easily bind to soil particles, which is why …

The imbalance of mitochondrial dynamics plays an important role in the pathogenesis of
cerebral ischemia/reperfusion (I/R) injury. Zinc-finger protein 36 (ZFP36) has been …

Mitochondria play an essential role in maintaining energy homeostasis and cellular survival.
In the brain, higher ATP production is required by mature neurons for communication. Most …

Epithelial-to-mesenchymal transition (EMT) is critical to the progression of several disease
processes including carcinoma metastasis and organ fibrosis. Recent studies show that …