Growth pattern of pancreatic islets in animals

C Hellerström, I Swenne - The diabetic pancreas, 1985 - Springer
Since the first edition of The Diabetic Pancreas, new facts and observations relevant to islet
growth have accumulated rapidly in the literature. Most of this concerns the B cell, but much …

Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates

O Blondel, D Bailbé, B Portha - Diabetes, 1989 - Am Diabetes Assoc
We assessed the impact of chronic insulin deficiency on basal and insulin-stimulated
glucose utilization by the whole-body mass in vivo in female albino Wistar rats. This …

Evaluation of neonatal streptozotocin induced diabetic rat model for the development of cataract

MA Patil, P Suryanarayana, UK Putcha… - Oxidative medicine …, 2014 - Wiley Online Library
Type 2 diabetes (T2D) generally follows prediabetes (PD) conditions such as impaired
fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Although studies reported an …

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background.

O Korsgren, L Jansson, S Sandler… - The Journal of clinical …, 1990 - Am Soc Clin Investig
The role of pancreatic B cell dysfunction in the phase preceding clinical onset of insulin-
dependent and non-insulin-dependent diabetes mellitus has been much debated. In this …

Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain

P Barragán-Iglesias, VH Oidor-Chan… - Pharmacological …, 2018 - Elsevier
Background The purpose of this study was to evaluate the participation of satellite glial cells
(SGC), microglia and astrocytes in a model of streptozotocin-induced diabetes initiated in …

[HTML][HTML] Treatment with Azadirachta indica in diabetic pregnant rats: negative effects on maternal outcome

B Dallaqua, FH Saito, T Rodrigues… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The role of Azadirachta indica (neem) against
Chagas disease and its antibiotic and antidiabetic action have been demonstrated in non …

Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment

O Blondel, D Bailbe, B Portha - Metabolism, 1990 - Elsevier
We have examined the effect of chronic (4 weeks) phlorizin treatment (osmotic minipumps)
on tissue sensitivity to insulin in adult female rats with non-insulin-dependent diabetes …

The metabolic responses to L-glutamine of livers from rats with diabetes types 1 and 2

JF Comar, DS de Oliveira, L Bracht, FS Kemmelmeier… - PLoS …, 2016 - journals.plos.org
There are several claims about the beneficial effects of supplementing L-glutamine to both
type 1 and type 2 diabetes. The purpose of the present study was to provide detailed …

Neonatally-induced diabetes: lipid profile outcomes and oxidative stress status in adult rats

YK Sinzato, PHO Lima, KE Campos… - Revista da Associacao …, 2009 - SciELO Brasil
BACKGROUND: Experimental models are developed for the purpose of enhancing the
understanding of the pathophysiological mechanisms involved in diabetes. Experimental …

Type 2 diabetes–a matter of failing β‐cell neogenesis? Clues from the GK rat model

J Movassat, S Calderari, E Fernández… - Diabetes, Obesity …, 2007 - Wiley Online Library
Now that reduction in β‐cell mass has been clearly established in humans with type 2
diabetes mellitus (T2D), the debate focuses on the possible mechanisms responsible for …