It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of
developing colorectal cancer (CRC). However, the underlying mechanisms are not entirely …

Context Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor
growth and metastases in animal models. However, the influence of aspirin on survival after …

Many human cancers express elevated levels of cyclooxygenase-2 (COX-2), an enzyme
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …

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Immuno-oncology (IO) is a young and growing field on the frontier of cancer therapy.
Contrary to cancer therapies that directly target malignant cells, IO therapies stimulate the …

Background Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis.
Angiogenesis (ie, the growth of new blood vessels) is closely associated with the incidence …

Piroxicam (PXM), a nonsteroidal anti-inflammatory drug, is an enolic benzothiazine and a
potent member of the oxicam series. The drug suppresses the synthesis of proinflammatory …

Introduction Gastric cancer (GC) has the higher genetic, cytologic, and architectural
heterogeneity compared to other gastrointestinal cancers. By inducing gastric inflammation …

Colorectal cancer is a major worldwide health care problem that accounts for 1 million new
cases each year. The risk factors for this disease include hereditary factors, environmental …