With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

Simple Summary Over 500,000 individuals died due to esophageal cancer (EC) worldwide
in 2020. More than four decades of etiological research have predominantly focused on the …

Posttranslational modifications add tremendous complexity to proteomes; however, gaps
remain in knowledge regarding the function and regulatory mechanism of newly discovered …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Abstract N6-methyladenosine (m6A) methylation is an abundant modification in eukaryotic
mRNAs. Accumulating evidence suggests a role for RNA m6A methylation in various …

Abstract MicroRNAs (miRNAs), small non-coding RNAs approximately 20–25 nt in length,
play important roles via directly binding to the corresponding 3′ UTR of target mRNAs …

Gastric cancer is one of the most lethal human malignancies in the world. Although great
efforts are put in developing novel therapeutic targets, the effective targeting drugs are still …

Background Metastasis is the leading cause of mortality in human cancers, including
esophageal squamous cell carcinoma (ESCC). As a pro-inflammatory cytokine, IL-32 was …

Esophageal cancer is a lethal malignancy with a high mortality rate, while the molecular
mechanisms underlying esophageal cancer pathogenesis are still poorly understood. Here …