Highlights•Halogenation is a powerful strategy to tune physicochemical features of organic
molecules.•Synthetic metabolism can be tailored for the incorporation of halogen …

The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …

The presence of mineral fluoride (F−) in the environment has both a geogenic and
anthropogenic origin, and the halide has been described to be toxic in virtually all living …

In recent years there has been a surge in the development of methods for the synthesis of
organofluorine compounds. However, enzymatic methods for C–F bond formation have …

Installing fluorine atoms onto natural products holds great promise for the generation of
fluorinated molecules with improved or novel pharmacological properties. The enzymatic …

Selective halogenation is necessary for a range of fine chemical applications, including the
development of therapeutic drugs. While synthetic processes to achieve C–H halogenation …

Enzyme-catalyzed stereodivergent synthesis to access all possible stereoisomers of
organofluorine compounds bearing multiple stereogenic centers remains an important and …

Enzymes capable of assimilating fluorinated feedstocks are scarce. This situation poses a
challenge for the biosynthesis of fluorinated compounds used in pharmaceuticals …

Difluorinated compounds are important structural motifs in organic synthesis and medicinal
chemistry because fluoride can modulate the properties of various molecules. In this paper …

Nucleoside analogs play a crucial role in the production of high-value antitumor and
antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid …