Highlights•Halogenation is a powerful strategy to tune physicochemical features of organic
molecules.•Synthetic metabolism can be tailored for the incorporation of halogen …

The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …

The presence of mineral fluoride (F−) in the environment has both a geogenic and
anthropogenic origin, and the halide has been described to be toxic in virtually all living …

In recent years there has been a surge in the development of methods for the synthesis of
organofluorine compounds. However, enzymatic methods for C–F bond formation have …

Difluorinated compounds are important structural motifs in organic synthesis and medicinal
chemistry because fluoride can modulate the properties of various molecules. In this paper …

Enzyme-catalyzed stereodivergent synthesis to access all possible stereoisomers of
organofluorine compounds bearing multiple stereogenic centers remains an important and …

The gene cluster in Streptomyces calvus associated with the biosynthesis of the fluoro‐and
sulfamyl‐metabolite nucleocidin was interrogated by systematic gene knockouts. Out of the …

The past several years have seen an increase in the discovery and isolation of natural
products of the indole alkaloid class. Bis-and tris-indole alkaloids are classes of natural …

Selective halogenation is necessary for a range of fine chemical applications, including the
development of therapeutic drugs. While synthetic processes to achieve C–H halogenation …

Leveraging the unique capabilities of pyrylium tetrafluoroborate for mechanochemical
deaminative arylation, this research navigates the complexities of N–C (O) activation in …