Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1-3 G …

The tumor suppressor p53 is mutationally inactivated in≈ 50% of human cancers.
Approximately one-third of the mutations lower the melting temperature of the protein …

A high-throughput screening campaign was conducted to interrogate a 380,000+ small-
molecule library for novel D2 dopamine receptor modulators using a calcium mobilization …

We report the development of homology models of dopamine (D2, D3, and D4), serotonin (5-
HT1B, 5-HT2A, 5-HT2B, and 5-HT2C), histamine (H1), and muscarinic (M1) receptors …

Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we
developed subtype selective dopamine receptor ligands of types 1a, c, 2a, and 3a …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

“Evolution consists largely of molecular tinkering.”—Following the famous concept of the
molecular geneticist and medicine Nobel laureate François Jacob, in this review we …

G-protein-coupled receptors (GPCRs) are considered therapeutically important due to their
involvement in a variety of processes governing several cellular functions, and their …

To understand the structural basis for the Na+-sensitivity of ligand binding to dopamine D2-
like receptors, using computational analysis in combination with binding assays, we …