Developmental selection and the perception of mutation bias
The notion that mutations are random relative to their fitness effects is central to the Neo-
Darwinian view of evolution. However, a recent interpretation of the patterns of mutation …
Darwinian view of evolution. However, a recent interpretation of the patterns of mutation …
Informatic Capabilities of Translation and Its Implications for the Origins of Life
The ability to encode and convert heritable information into molecular function is a defining
feature of life as we know it. The conversion of information into molecular function is …
feature of life as we know it. The conversion of information into molecular function is …
Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression
Increasing recombinant protein expression is of broad interest in industrial biotechnology,
synthetic biology, and basic research. Codon optimization is an important step in …
synthetic biology, and basic research. Codon optimization is an important step in …
A proteome-wide map of chaperone-assisted protein refolding in a cytosol-like milieu
The journey by which proteins navigate their energy landscapes to their native structures is
complex, involving (and sometimes requiring) many cellular factors and processes operating …
complex, involving (and sometimes requiring) many cellular factors and processes operating …
Resistance exercise stress: Theoretical mechanisms for growth hormone processing and release from the anterior pituitary somatotroph
WC Hymer, WJ Kraemer - European Journal of Applied Physiology, 2023 - Springer
Heavy resistance exercise (HRE) is the most effective method for inducing muscular
hypertrophy and stimulating anabolic hormones, including growth hormone, into the blood …
hypertrophy and stimulating anabolic hormones, including growth hormone, into the blood …
Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, S Kiehstaller, P Poc, AH Lewis, J Oh… - Chem, 2024 - cell.com
Proteins are essential biomolecules and central to biotechnological applications. In many
cases, assembly into higher-order structures is a prerequisite for protein function. Under …
cases, assembly into higher-order structures is a prerequisite for protein function. Under …
Curse and Blessing of Non‐Proteinogenic Parts in Computational Enzyme Engineering
KT Korbeld, MJLJ Fürst - ChemBioChem, 2023 - Wiley Online Library
Enzyme engineering aims to improve or install a new function in biocatalysts for applications
ranging from chemical synthesis to biomedicine. For decades, computational techniques …
ranging from chemical synthesis to biomedicine. For decades, computational techniques …
How soluble misfolded proteins bypass chaperones at the molecular level
Subpopulations of soluble, misfolded proteins can bypass chaperones within cells. The
extent of this phenomenon and how it happens at the molecular level are unknown. Through …
extent of this phenomenon and how it happens at the molecular level are unknown. Through …
Engineering Ag43 signal peptides with bacterial display and selection
Protein display, secretion, and export in prokaryotes are essential for utilizing microbial
systems as engineered living materials, medicines, biocatalysts, and protein factories. To …
systems as engineered living materials, medicines, biocatalysts, and protein factories. To …
Development of a new affinity maturation protocol for the construction of an internalizing anti-nucleolin antibody library
R Ribeiro, JN Moreira, J Goncalves - Scientific Reports, 2024 - nature.com
Over the last decades, monoclonal antibodies have substantially improved the treatment of
several conditions. The continuous search for novel therapeutic targets and improvements in …
several conditions. The continuous search for novel therapeutic targets and improvements in …