Mouse models of sickle cell disease: imperfect and yet very informative
S Kamimura, M Smith, S Vogel, LEF Almeida… - Blood Cells, Molecules …, 2024 - Elsevier
The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …
few therapies to treat the disease are available. Over several decades of work, with …
[HTML][HTML] Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis
CV Lewis, H Sellak, MA Sawan, G Joseph… - Faseb …, 2023 - ncbi.nlm.nih.gov
The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell
disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier …
disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier …
Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice
L Xiao, K Clarke, MM Hurley - Endocrinology, 2023 - academic.oup.com
We assessed the involvement of fibroblast growth factor 23 (FGF23) in phosphaturia in
sickle cell disease (SCD) mice. Control and SCD mice were treated with FGF23 neutralizing …
sickle cell disease (SCD) mice. Control and SCD mice were treated with FGF23 neutralizing …
[HTML][HTML] Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait
Sickle cell disease (SCD) is caused by the homozygous beta-globin gene mutation that can
lead to ischemic multi-organ damage and consequently reduce life expectancy. On the other …
lead to ischemic multi-organ damage and consequently reduce life expectancy. On the other …
Installation of HbG-Makassar by base editing restores hemoglobin function: a transformative therapy for sickle cell disease
V Sheehan, Z Kostamo, M Ortega, C Xu, P Feliciano… - 2024 - researchsquare.com
Adenine base editing offers a viable gene-based therapy for sickle cell disease (SCD),
converting sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a …
converting sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a …
Investigating the Role of Complement in Sickle Cell Disease
D Diatlov - 2023 - search.proquest.com
Sickle cell disease (SCD) is an understudied life-threatening genetic disorder affecting
around 300,000 infants yearly with severely limited treatment options. Recent research …
around 300,000 infants yearly with severely limited treatment options. Recent research …