Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-
restricted proliferating precursors in culture; however, this has not been demonstrated in …

Spinal cord injury (SCI) leads to irreversible neuronal loss and glial scar formation, which
ultimately result in persistent neurological dysfunction. Cellular regeneration could be an …

Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately
involved in learning and memory, mood, and stress response. Despite considerable …

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that
two small molecules (forskolin and dorsomorphin) enable the transcription factor …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Glial cells can be in vivo reprogrammed into functional neurons in the adult CNS; however,
the process by which this reprogramming occurs is unclear. Here, we show that a distinct …