Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …

Intervertebral disc (IVD) herniation and degeneration contributes significantly to low back
pain (LBP), of which the molecular pathogenesis is not fully understood. Disc herniation may …

Neuropathic pain remains a pressing clinical problem. Here, we demonstrate that a local,
intrathecal (it) injection of bone marrow stromal cells (BMSCs) following lumbar puncture …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Current treatments for chronic pain, such as inflammatory pain, neuropathic pain, and
cancer pain are insufficient and cause severe side effects. Mounting evidence suggests that …

Peripheral nerve lesion triggers alterations in the spinal microenvironment that contribute to
the pathogenesis of neuropathic pain. While neurons and glia have been implicated in these …

Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …