Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
A Ofoghi, S Kotschi, IL Lemmer, DT Haas… - Cell Death & …, 2024 - nature.com
Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative
stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the …
stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the …
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo
S Mukherjee, M Chakraborty, EN Msengi… - Molecular …, 2023 - Elsevier
Objective Defining the regulators of cell metabolism and signaling is essential to design new
therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse …
therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse …
[HTML][HTML] DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
M Nedomova, S Haberecht-Müller, S Möller, S Venz… - Iscience, 2024 - cell.com
DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic
stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining …
stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining …
Repair of genomic interstrand crosslinks
MA Bellani, A Shaik, I Majumdar, C Ling, MM Seidman - DNA repair, 2024 - Elsevier
Genomic interstrand crosslinks (ICLs) are formed by reactive species generated during
normal cellular metabolism, produced by the microbiome, and employed in cancer …
normal cellular metabolism, produced by the microbiome, and employed in cancer …
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
A Bartelt, A Ofoghi, S Kotschi, I Lemmer, N Willemsen… - 2023 - researchsquare.com
Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative
stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the …
stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the …