How can single cells without nervous systems perform complex behaviours such as
habituation, associative learning and decision making, which are considered the hallmark of …

Highlights•CA domain of bacterial HKs presents a novel anti-virulence or antibiotic
target.•CA domain targeted molecules can inhibit multiple HKs, increasing effectiveness.• …

Motile bacteria sense chemical gradients with transmembrane receptors organised in
supramolecular signalling arrays. Understanding stimulus detection and transmission at the …

The Per–Arnt–Sim (PAS; named for the representative proteins: Period, Aryl hydrocarbon
receptor nuclear translocator protein and Single-minded) domain of the dimeric Escherichia …

Membrane-associated proteins are important because they mediate interactions between a
cell's external and internal environment and they are often targets of therapeutics …

Chemotaxis signaling pathways enable bacteria to sense and respond to their chemical
environment and, in some species, are critical for lifestyle processes such as biofilm …

The Escherichia coli chemoreceptor array is a supramolecular assembly that enables cells
to respond to extracellular cues dynamically and with great precision and sensitivity. In the …

The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in
biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 …

Vibrio cholerae, the causative agent of the acute diarrheal disease cholera, is able to thrive
in diverse habitats such as natural water bodies and inside human hosts. To ensure their …

Advancements in the field of cryo-electron tomography have greatly contributed to our
current understanding of prokaryotic cell organization and revealed intracellular structures …