Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

Gold nanoparticles display unique physicochemical features, which can be useful for
therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are …

Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …

G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology
across human tissues in response to extracellular signals. GPCR-mediated signalling can …

Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene
expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 …

Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can
carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can …

RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …

Recent years have witnessed tremendous developments and breakthroughs in the field of
RNA-based therapeutics. The distinct mechanisms of exogenous RNAs and analogs …

MicroRNAs (miRNAs) are a new therapeutic tool that can target multiple genes by inducing
translation repression and target mRNA degradation. Although miRNAs have gained …