Biologics, both monoclonal antibodies (mAbs) and fusion proteins, have revolutionized the
practice of medicine. This year marks the 30th anniversary of the Food and Drug …

Neuromyelitis optica (NMO) and spectrum disorder (NMO/SD) represent a vexing process
and its clinical variants appear to have at their pathogenic core the loss of immune tolerance …

Antigen recognition of peptide-major histocompatibility complexes (pMHCs) by T cells, a key
step in initiating adaptive immune responses, is performed by the T cell receptor (TCR) …

Cancer onset and progression involves the accumulation of multiple oncogenic hits, which
are thought to dominate or bypass the physiologic regulatory mechanisms in tissue …

Objective: To explore a better anesthesia method for the patients with gastric cancer who will
undergo operation by investigating the impact of different anesthesia methods on stress …

Adoptive cell transfer (ACT) is a type of personalized immunotherapy in which expanded
immune cells are administered to patients with cancer. However, single-cell populations …

Activation of the T cell receptor (TCR) leads to a network of early signaling predominantly
orchestrated by tyrosine phosphorylation in T cells. The TCR is commonly activated using …

Monoclonal antibodies have been successfully utilized in a variety of animal models to treat
auto-immune illnesses for a long time. Immune system responses will either be less active or …

Advancements in science enable researchers to constantly innovate and create novel
biologics. However, the use of non-human animal models during the development of …

The agonistic anti-human CD3ε antibody (Ab), OKT3, has been used to control acute
transplant rejection. The in vivo administration of OKT3 was previously shown to induce the …