Multisystem physiological perspective of human frailty and its modulation by physical activity
JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
Aging and imaging assessment of body composition: from fat to facts
The aging process is characterized by the chronic inflammatory status called
“inflammaging”, which shares major molecular and cellular features with the metabolism …
“inflammaging”, which shares major molecular and cellular features with the metabolism …
[HTML][HTML] Inflammation and frailty in the elderly: a systematic review and meta-analysis
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …
the evidence considering the relationship between inflammation and frailty through a …
Strategies to prevent sarcopenia in the aging process: role of protein intake and exercise
PS Rogeri, R Zanella Jr, GL Martins, MDA Garcia… - Nutrients, 2021 - mdpi.com
Sarcopenia is one of the main issues associated with the process of aging. Characterized by
muscle mass loss, it is triggered by several conditions, including sedentary habits and …
muscle mass loss, it is triggered by several conditions, including sedentary habits and …
Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
Osteoporosis and sarcopenia increase frailty syndrome in the elderly
EA Greco, P Pietschmann, S Migliaccio - Frontiers in endocrinology, 2019 - frontiersin.org
Musculoskeletal aging is a major public health interesting and strain due to the significant
demographic modifications in the population, and it is linked to high risk of falls, loss of …
demographic modifications in the population, and it is linked to high risk of falls, loss of …
Age-related changes in skeletal muscle: changes to life-style as a therapy
R McCormick, A Vasilaki - Biogerontology, 2018 - Springer
As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia
A Uezumi, M Ikemoto-Uezumi, H Zhou… - The Journal of …, 2021 - Am Soc Clin Investig
Age-related sarcopenia constitutes an important health problem associated with adverse
outcomes. Sarcopenia is closely associated with fat infiltration in muscle, which is …
outcomes. Sarcopenia is closely associated with fat infiltration in muscle, which is …
Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
J Angulo, M El Assar, L Rodriguez-Manas - Molecular aspects of medicine, 2016 - Elsevier
Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …
Interactions between muscle and bone—where physics meets biology
M Herrmann, K Engelke, R Ebert, S Müller-Deubert… - Biomolecules, 2020 - mdpi.com
Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …
Physical forces are generated through gravity, locomotion, exercise, and external devices …