It is now slightly more than a decade since Michael Berridge and his collaborators reported
in Nature “… micromolar concentrations of Ins (1, 4, 5) P3 (1d‐myo‐inositol 1, 4, 5 …

I. Introduction....................................................................... 215 II. IMPase Inhibitors...........................
....................................... 216 A. Nonlithium Cations.............................................................. 216 B …

The first successful preparation of mono-and disubstituted 3, 7-dihydroxytropolone involves
a four-step synthetic scheme. Thus, bromination of 3, 7-dihydroxytropolone (8) followed by …

α-Hydroxyphosphonates are moderately potent (Ki= 6–600μM) inhibitors of the enzyme myo-
inositol monophosphatase (McLeod et al., Med. Chem. Res. 1992, 2, 96). Hydroxy-[4-(5, 6 …

Zu einer Renaissance in der Inositphosphatchemie hat die Entdeckung der Rolle von myo‐
Inosit‐1, 4, 5‐trisphosphat 1 als sekundärer Botenstoff vor zwölf Jahren geführt: Es wurden …

Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol
monophosphates to myo-inositol. which is required in the phosphatidyl inositol cell …

The design and synthesis of inhibitors of inositol monophosphatase (IMPase, EC 3.1. 3.25)
based on natural substrates and lead compounds discovered by screening is discussed …

SYNTHESIS OF NOVEL ANALOGUES OF MYO-INOSITOL 1,4,5- TRISPHOSPHATE submitted
by Dethard Lampe for the degree of PhD of the Univer Page 1 SYNTHESIS OF NOVEL …

The enzyme, myo-inositol monophosphatase (IMPase), converts myo-inositol 1-phosphate
to myo-inositol and is involved in the phosphatidylinositol cell signalling pathway. Inhibitors …

Synthesis of Racemic myo-lnositol 1,4,5-Trisphosphate 3-O-Methylenecarboxylate, a CaZ+-Mobilising
myo-lnositol 1,3,4,5-Tetrakisp Page 1 J. CHEM. soc., CHEM. COMMUN., 1993 1687 …