Emerging lymphatic imaging technologies for mouse and man

EM Sevick-Muraca, S Kwon… - The Journal of clinical …, 2014 - Am Soc Clin Investig
The lymphatic circulatory system has diverse functions in lipid absorption, fluid homeostasis,
and immune surveillance and responds dynamically when presented with infection …

Image‐guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies

P Dogra, JD Butner, S Nizzero… - Wiley …, 2020 - Wiley Online Library
While plasma concentration kinetics has traditionally been the predictor of drug
pharmacological effects, it can occasionally fail to represent kinetics at the site of action …

Biomimetic Fe-Cu dual-atomic-site catalysts enable efficient H2O2 activation for tumor lymphatic metastasis inhibition

L Jiao, N Tao, Y Kang, W Song, Y Chen, Y Zhang… - Nano Today, 2023 - Elsevier
Achieving efficient activation of H 2 O 2 in the tumor microenvironment (TME) and further
improving the therapeutic efficiency is a great challenge in chemodynamic therapy against …

Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis

ST Proulx, P Luciani, A Christiansen, S Karaman… - Biomaterials, 2013 - Elsevier
Tumor lymphangiogenesis promotes metastatic cancer spread to lymph nodes and beyond.
However, the potential remodeling and functionality of tumor-draining lymphatic vessels has …

Unimolecular nano-contrast agent with ultrahigh relaxivity and very long retention for magnetic resonance lymphography

L Xu, Q Zhang, L Lu, Y Shi, L Liu, J Shen, Y Chen - Nano Letters, 2022 - ACS Publications
Magnetic resonance (MR) imaging is very important for noninvasive lymphography.
However, the present MR contrast agents still cannot supply strong enough tissue contrast …

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes

X Huang, F Zhang, S Lee, M Swierczewska… - Biomaterials, 2012 - Elsevier
The imaging of sentinel lymph nodes (SLNs), the first defense against primary tumor
metastasis, has been considered as an important strategy for noninvasive tracking tumor …

[HTML][HTML] Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Mode Imaging of Lymph Nodes with Metastatic Tumors

L Tang, X Yang, LW Dobrucki, I Chaudhury… - … (International ed. in …, 2012 - ncbi.nlm.nih.gov
Metastases are responsible for 90% of human cancer deaths.[1] Most solid tumors
metastasize through the circulation system, and the sentinel lymph node (LN) is typically the …

Copper sulfide perfluorocarbon nanodroplets as clinically relevant photoacoustic/ultrasound imaging agents

DY Santiesteban, DS Dumani, D Profili… - Nano …, 2017 - ACS Publications
We have developed laser-activated perfluorocarbon nanodroplets containing copper sulfide
nanoparticles (CuS NPs) for contrast-enhanced ultrasound and photoacoustic imaging. As …

Relaxivity Enhancement of Hybrid Micelles via Modulation of Water Coordination Numbers for Magnetic Resonance Lymphography

Y Jiang, Z Cai, S Fu, H Gu, X Fu, J Zhu, Y Ke… - Nano Letters, 2023 - ACS Publications
Considerable efforts have been made to develop nanoparticle-based magnetic resonance
contrast agents (CAs) with high relaxivity. The prolonged rotational correlation time (τR) …

[HTML][HTML] Cabazitaxel-loaded Poly (2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft

M Fusser, A Øverbye, AD Pandya, Ý Mørch… - Journal of controlled …, 2019 - Elsevier
The effect of poly (2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug
cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived …