Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …
[HTML][HTML] Dynamics in Cre-loxP site-specific recombination
MP Foster, MJ Benedek, TD Billings… - Current Opinion in …, 2024 - Elsevier
Cre recombinase is a phage-derived enzyme that has found utility for precise manipulation
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …
Activation of recombinases at specific DNA loci by zinc-finger domain insertions
L Mukhametzyanova, LT Schmitt, J Torres-Rivera… - Nature …, 2024 - nature.com
Recombinases have several potential advantages as genome editing tools compared to
nucleases and other editing enzymes, but the process of engineering them to efficiently …
nucleases and other editing enzymes, but the process of engineering them to efficiently …
Unraveling the role of ZNF506 as a human PBS-pro-targeting protein for ERVP repression
Krüppel-associated box zinc finger proteins (KZFPs) function as a defense mechanism to
maintain the genome stability of higher vertebrates by regulating the transcriptional activities …
maintain the genome stability of higher vertebrates by regulating the transcriptional activities …
Quantification of evolved DNA-editing enzymes at scale with DEQSeq
LT Schmitt, A Schneider, J Posorski, F Lansing… - Genome Biology, 2023 - Springer
We introduce DEQSeq, a nanopore sequencing approach that rationalizes the selection of
favorable genome editing enzymes from directed molecular evolution experiments. With the …
favorable genome editing enzymes from directed molecular evolution experiments. With the …
Engineering spacer specificity of the Cre/loxP system
J Hoersten, G Ruiz-Gómez… - Nucleic Acids …, 2024 - academic.oup.com
Translational research on the Cre/loxP recombination system focuses on enhancing its
specificity by modifying Cre/DNA interactions. Despite extensive efforts, the exact …
specificity by modifying Cre/DNA interactions. Despite extensive efforts, the exact …
Anticancer potential of isovanillin-based symmetrical azine: Synthesis, structure, molecular modeling, in silico leukemia inhibition and MD simulation
K Fadli, A Bouchama, A Tabbiche, C Chiter… - Journal of Molecular …, 2024 - Elsevier
Isovanillin azine, a symmetrical azine easily synthesized by reaction of 3-hydroxy-4-
methoxybenzaldehyde (isovanillin) with hydrazine hydrate, was identified as a potential …
methoxybenzaldehyde (isovanillin) with hydrazine hydrate, was identified as a potential …
Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN 2023)
C de Mendoza, G Taylor, A Gessain… - NeuroImmune …, 2024 - degruyter.com
The 30th workshop of the HTLV European Research Network (HERN) was held in Madrid
on September 15–16, 2023. Over fifty researchers from Europe and America convened for a …
on September 15–16, 2023. Over fifty researchers from Europe and America convened for a …
Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN
The 30th workshop of the HTLV European Resea rch Network (HERN) was held in Madrid
on September 15–16, 2023. Over fifty researchers from Europe and America convened for a …
on September 15–16, 2023. Over fifty researchers from Europe and America convened for a …