Prostate cancer is a global health problem, but incidence varies considerably across
different continents. Asia is traditionally considered a low-incidence area, but the incidence …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

摘要前列腺癌是西方国家老年男性常见的恶性肿瘤. 近十余年来, 中国前列腺癌发病率及死亡率
均呈快速上升趋势. 随着社会经济, 生活方式的变化以及诊断治疗手段的进步 …

Aims To evaluate current status of prostate cancer incidence and mortality worldwide, and
compare the global trends of incidence and mortality in the past two decades and in the …

Abstract The Genome Sequence Archive (GSA) is a data repository for archiving raw
sequence data, which provides data storage and sharing services for worldwide scientific …

Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …

Integrated molecular analysis of human cancer has yielded molecular classification for
precise management of cancer patients. Here, we analyzed the whole genomic …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

Cellular senescence (CS), a state of permanent growth arrest, is intertwined with
tumorigenesis. Due to the absence of specific markers, characterizing senescence levels …