Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …

Abstract Purpose of Review Ankylosing spondylitis (AS) is strongly associated with the HLA-
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …

The Wilms' tumor gene WT1 is expressed at high levels not only in acute myelocytic and
lymphocytic leukemia and in chronic myelocytic leukemia but also in various types of solid …

CD4+ class II–restricted T cells specific for self antigens are thought to be involved in the
pathogenesis of most human autoimmune diseases and molecular mimicry between foreign …

In the 15 years since their first description, the conceptual and technical approaches that
encompass combinatorial chemistry have gained wide acceptance across virtually all …

The field of combinatorial peptide chemistry has emerged as a powerful tool in the study of
many biological systems. This review focuses on combinatorial peptide library methodology …

Recent studies have demonstrated flexibility of the T-cell receptor (TCR) with respect to
recognition of peptide bound to self major histocompatibility complex (MHC). With the …

The definition of epitopes for human B and T cells is fundamental for the understanding of
the immune response mechanism and its role in the prevention and cause of human …

Peptide-based vaccine development needs accurate prediction of the binding affinity
between major histocompatibility complex I (MHC I) proteins and their peptide ligands …

Miniproteins provide a bridge between proteins and small molecules. Here we adapt
methods from combinatorial chemistry to optimize CD4M33, a synthetic miniprotein into …