Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …

The use of patient-derived tumor tissues and cells has led to significant advances in
personalized cancer therapy and precision medicine. The advent of genomic sequencing …

Prostate cancer (PCa) has been known as the most prevalent cancer disease and the
second leading cause of cancer mortality in men almost all over the globe. There is an …

The tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-
cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells. The …

Introduction Immunotherapies have revolutionized cancer treatment, but often fail to produce
desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and …

Developing in vitro models that accurately mimic the microenvironment of biological
structures or processes holds substantial promise for gaining insights into specific biological …

Despite conventional therapy, lupus nephritis (LN) remains a significant contributor to short-
and long-term morbidity and mortality. B cell abnormalities and the production of …

Simple Summary The recently identified lysine methyltransferase (KMT) 9 regulates the
growth of different types of cancer. While KMT9 was shown to be overexpressed in muscle …

Organoids are three-dimensional cellular structures designed to recreate the biological
characteristics of the body's native tissues and organs in vitro. There has been a recent …

In immunotherapy, the immune system is modulated in order to treat cancer. Traditional two
dimensional in vitro models and in vivo animal models are insufficient to simulate the …