The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …

Surgical resection is the only option of cure for patients with metastatic colorectal cancer
(CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75 …

Colorectal cancer (CRC) is one of the most common cancers globally as well as in Japan
and has shown a pattern of increasing incidence and mortality rates. Therefore, guidelines …

Highlights•This article provides ESMO expert recommendations adapted for the treatment of
localised colon cancer in Asian patients.•The aim was to provide guidance for the …

Background The aim of this study was to clarify clinicopathological features, frequencies of
molecular biomarkers, and prognoses in Japanese colorectal cancer patients and compare …

Background Adjuvant chemotherapy with oral fluoropyrimidine alone after D3/D2 lymph
node dissection improves disease-free survival and overall survival in patients with stage III …

Background: Postoperative 1-year administration of S-1, an oral derivative of 5-fluorouracil
(5-FU), was shown to be feasible in lung cancer. The 5-year survival rates of postoperative …

Fluorouracil (5FU) is the backbone chemotherapy agent in the treatment of colorectal cancer
(CRC). Cardiotoxicity represents an uncommon but serious side effect of treatment with 5FU …

Backgrounds Preventing distant recurrence and achieving local control are important
challenges in rectal cancer treatment, and use of adjuvant chemotherapy has been studied …

Surgical resection and adjuvant chemotherapy are the only treatment modalities for
localized colorectal cancer that can obtain a “cure.” The goal in surgically treating primary …